Visfatin是新近发现的一种脂肪细胞因子,通过与胰岛素受体结合激活胰岛素信号转导通路,具有类胰岛素样作用。它的分泌受体内多种因素的调节,如激素、游离脂肪酸、葡萄糖。在代谢综合征相关疾病的发生发展过程中起重要作用,但目前对visfatin的研究存在很大争议,其作用机制有待于进一步探讨。 Visfatin, a newly discovered adipocytokines, has the insulin-like effect by activating the insulin signal transduction pathway by binding to the insulin receptor. Its secretion is regulated by a variety of factors in the body, such as hormones, free fatty acids, glucose. It plays an important role in the development and progression of metabolic syndrome-related diseases. However, the current research on visfatin is controversial and its mechanism remains to be further explored.