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吸入气雾剂(MDIs)中抛射剂氟利昂(CFC)的替代并非制剂中简单的辅料替换。综述了氢氟烷烃(HFA)替代CFC过程中所涉及的处方组成改变、工艺参数优化、给药装置的选择、制药设备的更新以及产业化过程中的特殊要求。
The replacement of the propellant freon (CFC) in inhaled aerosols (MDIs) is not a simple excipient replacement in the formulation. This review summarizes the changes in prescription composition, the optimization of process parameters, the selection of drug delivery devices, the renewal of pharmaceutical equipment and the special requirements in the industrialization process involved in the replacement of HFCs with CFCs.