Recurrence risk model for esophageal cancer after radical surgery

来源 :Chinese Journal of Cancer Research | 被引量 : 0次 | 上传用户:mmcemil
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective:The aim of the present study was to construct a risk assessment model which was tested by disease-free survival(DFS)of esophageal cancer after radical surgery.Methods:A total of 164 consecutive esophageal cancer patients who had undergone radical surgery between January 2005 and December 2006 were retrospectively analyzed.The cutpoint of value at risk(VaR)was inferred by stem-and-leaf plot,as well as by independent-samples t-test for recurrence-free time,further confirmed by crosstab chi-square test,univariate analysis and Cox regression analysis for DFS.Results:The cutpoint of VaR was 0.3 on the basis of our model.The rate of recurrence was 30.3%(30/99)and 52.3%(34/65)in VaR<0.3 and VaR≥0.3(chi-square test,χ2=7.984,P=0.005),respectively.The 1-,3-,and 5-year DFS of esophageal cancer after radical surgery was 70.4%,48.7%,and 45.3%,respectively in VaR≥0.3,whereas 91.5%,75.8%,and 67.3%,respectively in VaR<0.3(Log-rank test,χ2=9.59,P=0.0020),and further confirmed by Cox regression analysis[hazard ratio=2.10,95%confidence interval(CI):1.2649-3.4751;P=0.0041].Conclusions:The model could be applied for integrated assessment of recurrence risk after radical surgery for esophageal cancer. Objective: The aim of the present study was to construct a risk assessment model which was tested by disease-free survival (DFS) of esophageal cancer after radical surgery. Methods: A total of 164 consecutive esophageal cancer patients who had undergone radical surgery between January 2005 and December 2006 were retrospectively analyzed. The cutpoint of value at risk (VaR) was inferred by stem-and-leaf plot, as well as by independent-samples t-test for recurrence-free time, further confirmed by crosstab chi-square test, univariate analysis and Cox regression analysis for DFS. Results: The cutpoint of VaR was 0.3 on the basis of our model. The rate of recurrence was 30.3% (30/99) and 52.3% (34/65) in VaR <0.3 and VaR ≥0.3 (chi-square test, χ2 = 7.984, P = 0.005), respectively.The 1-, 3- and 5-year DFS of esophageal cancer after radical surgery was 70.4%, 48.7%, and 45.3% respectively in VaR <0.3, while 91.5%, 75.8%, and 67.3% respectively in VaR <0.3 (Log-rank test, X2 = 9.59, P = 0.0020), and further confirmed by Cox reg ression analysis [hazard ratio = 2.10, 95% confidence interval (CI): 1.2649-3.4751; P = 0.0041] .Conclusions: The model could be applied for integrated assessment of recurrence risk after radical surgery for esophageal cancer.
其他文献
Compared with conventional method of violet spectrum,determination of the content of sulfides in fluid catalytic cracking(FCC)gasoline by using the potentiometr
分别在酸性和碱性介质研究了铬天青S(CAS),溴甲酚绿(BCG),溴邻苯三酚红(BPR)和甲基百里酚蓝(MTB)与蛋白质结合的光度性质.在pH 3.8~4.0,蛋白质使CAS和BCG的吸光度降低,在pH 3.
The sensitive second derivative waves of Cu(Ⅱ), Pb( Ⅱ ), Cd( Ⅱ ), Ni( Ⅱ ), Zn( Ⅱ ), Fe( Ⅱ ) and Mn( Ⅱ ), forming in the substrate solution (pH=9.26) cons
The solidification structure of Bi-3 wt pct Mn alloy grown up in the semisolid zone under the influence of a static magnetic field (up to 1.0 T) and the relatio
在实际应用中,传统多目标演化算法面临着高维多目标优化问题.针对这一缺陷,提出正交E占优(Orthogonality E-dominant,OE)策略.在OE策略的理论优越性设计的基础上,改进了当前5
以SCI收录的知识研究相关文献为对象,对国际知识管理研究的领域分布情况进行知识地图分析.引入G-N聚类算法,对知识管理研究的领域知识地图进行聚类分析.研究表明,知识管理研