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目的:探讨婴幼儿巨细胞病毒(CMV)肝炎的相关因素。方法:选择2010年2月~2013年6月在广东省妇幼保健院诊治的118例CMV肝炎婴幼儿为研究对象(病例组),选择同期118例健康婴幼儿为对照组。对婴幼儿CMV肝炎的相关因素进行分析。结果:病例组CMV肝炎患儿发病月龄以1~3月龄所占比例(70.34%)居多,病例组婴幼儿来自农村的比例较高,且病例组婴幼儿父母文化程度普遍较低,母乳CMV-DNA阳性比例(74.58%)明显高于对照组(22.88%)(P<0.05)。病例组婴幼儿月龄、居住地、父母文化程度及母乳CMV-DNA阳性等因素和对照组相比,差异有统计学意义(P<0.05)。婴幼儿低月龄(OR=5.367,95%CI:2.451~11.755)、居住地为农村(OR=5.778,95%CI:1.963~17.009)、母乳CMV-DNA阳性(OR=5.178,95%CI:3.963~18.009)及父母文化程度低(OR=4.962,95%CI:2.958~16.016)等4项因素和婴幼儿CMV肝炎密切相关,为婴幼儿CMV肝炎的独立危险因素。结论:婴幼儿低月龄、居住地为农村、母乳CMV感染及父母文化程度低为婴幼儿CMV肝炎的独立危险因素。加强对这些危险因素的重视和干预,可以在一定程度上减少婴幼儿CMV肝炎的发生。
Objective: To investigate the related factors of infantile cytomegalovirus (CMV) hepatitis. Methods: A total of 118 cases of CMV hepatitis patients treated in Guangdong Maternal and Child Health Hospital from February 2010 to June 2013 were selected as the study subjects (case group). 118 healthy infants were selected as the control group. The factors related to infant CMV hepatitis were analyzed. Results: The age of onset of CMV hepatitis cases was mostly in the range of 1 ~ 3 months (70.34%) in the case group, the proportion of infants and young children in the case group was higher than that in the rural areas, and the infants in the case group were generally lower in educational level. The positive proportion of CMV-DNA (74.58%) was significantly higher than that of the control group (22.88%) (P <0.05). There were significant differences in age, place of residence, parents’ educational level and CMV-DNA positive rate of breast milk between the two groups as compared with the control group (P <0.05). Low-age infants (OR = 5.367, 95% CI: 2.451-11.755), rural residents (OR = 5.778, 95% CI: 1.963-17.009) and CMV- DNA positive for breast milk (OR = 5.178, 95% CI : 3.963 ~ 18.009) and parents with low educational level (OR = 4.962, 95% CI: 2.958 ~ 16.016) and other four factors and infant CMV hepatitis are closely related to infant CMV hepatitis independent risk factors. Conclusion: Infants with low age and living in rural areas, breast-milk CMV infection and parents with low educational level are independent risk factors for infant CMV hepatitis. Strengthening the emphasis on these risk factors and intervention can reduce the incidence of CMV hepatitis in infants and young children to a certain extent.