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目的:探讨多学科协作诊疗口腔颌面部及颈部多间隙感染合并下行性坏死性纵隔炎的策略及经验。方法:纳入2011年7月至2019年7月郑州大学第一附属医院口腔颌面外科收治的36例口腔颌面部及颈部多间隙感染合并下行性坏死性纵隔炎患者。对患者的临床资料进行回顾性分析，包括患者性别、年龄、入院时症状、感染来源、术前及术后评估指标、多学科协作诊疗策略及预后等。结果:36例患者中男性26例，女性10例，年龄（51.6±17.6）岁（8~80岁），就诊前病程为（8.9±8.4）d（2~30 d）。患者均以颌面颈部肿胀、疼痛为主诉入院，其中牙源性感染占39%（14/36），咽喉口底肿胀疼痛者占25%（9/36），不明原因颌面肿胀者占36%（13/36）。28例患者行手术治疗，8例患者因全身合并症多不能耐受手术；治愈26例（72%），死亡10例（28%）。经手术为主的多学科协作诊疗患者术后各研究时间点白细胞、中性粒细胞、C反应蛋白及降钙素原水平较入院时均显著降低（n P<0.05），患者住院时长与入院时C反应蛋白（n r=0.545，n P<0.05）、降钙素原水平（n r=0.504，n P<0.05）均呈正相关关系。经手术为主的多学科联合治疗患者生存率（26/28）显著好于未行手术患者（0/8）（n P<0.01）。n 结论:口腔颌面部及颈部多间隙感染合并下行性坏死性纵隔炎患者的病情危重，多学科协作诊疗对改善患者预后至关重要；白细胞计数、中性粒细胞百分比、C反应蛋白及降钙素原水平的监测可以有效地观察患者病情变化情况。“,”Objective:To explore the strategy and experience for treating maxillofacial and cervical multi-space infection combined with descending necrotizing mediastinitis (DNM) via multidisciplinary team (MDT) collaboration.Methods:A total of 36 patients with maxillofacial and cervical multi-space infection complicated with DNM admitted to the First Affiliated Hospital of Zhengzhou University from July 2011 to July 2019 were included in the study. The clinical data of the patients were retrospectively analyzed, including gender, age, symptoms at admission, source of infection, preoperative and postoperative evaluation indicators, MDT strategy and prognosis.Results:There were 26 males and 10 females with an average age of (51.6±17.6) years (8-80 years). The course of disease before admission was (8.9±8.4) days (2-30 days). All patients were admitted with maxillofacial and neck swelling and pain as the main complaints. Odontogenic infection accounted for 39% (14/36), throat floor swelling and pain accounted for 25% (9/36) and unknown maxillofacial swelling accounted for 36% (13/36). There were 28 cases receiving surgical treatment, 26 cases were cured and discharged (72%), 10 cases died (28%). In the patients treated with multidisciplinary therapy (mainly by surgery), the white blood cell count, neutrophil percentage, C-reactive protein and procalcitonin levels were significantly improved compared with those at admission at each observation time point after operation (n P<0.05). The length of stay was positively correlated with the levels of C-reactive protein (n r=0.545, n P<0.05) and procalcitonin (n r=0.504, n P<0.05). The prognosis of patients treated with surgery (26/28) was better than that of patients without surgery (0/8) (n P<0.01).n Conclusions:The patients with maxillofacial and cervical multi-space infection combined with DNM might be in critical condition. The surgical based MDT strategy has an important impact on the prognosis of patients. White blood cell count and other inflammatory indicators monitoring can effectively observe the changes of the patient′s condition.