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应用ＷＨＯ推荐的体外微量测定法于停用氯喹前的１９８１年及停药后的１９８４、１９８８—１９９０和１９９２年在云南省南部的勐腊县测得恶性疟原虫对氯喹的抗性率分别为９７．４％、１００％、９６．１％及９３．７％；ＩＤ５０依次为１７０、１３２、１２５及１１０ｎｍｏｌ／Ｌ，ＩＤ９５为１０００、７４０、７０７及５７６ｎｍｏｌ／Ｌ；平均抑制量分别为５５．４、４６．７、４５．８及３５．４ｐｍｏ１／井。与１９８１年测得结果相比，抗性率无明显变化；ＩＤ５０分别下降２２．３％（Ｐ＜０．０５）、２６．４％（Ｐ＜０．０５）及３５．３％（Ｐ＜０．０１），ＩＤ９５依次下降２６．０％（Ｐ＜０．０５）、２９．３％（Ｐ＜０．０５）及４２．４％（Ｐ＜０．０１）。平均抑制量分别下降１５．７％（Ｐ＞０．０５）、１７．３％（Ｐ＜０．０５）及３６．１％（Ｐ＜０．０１）。提示云南南部恶性疟原虫对氯喹的抗性并不稳定，而是随药物压力的下降而降低。
The resistance rates of Plasmodium falciparum to chloroquine measured in 1981 in vitro before chloroquine withdrawal and after discontinuation in 1984, 1988-1990 and 1992 in Mengla County, southern Yunnan Province, using the WHO in vitro microassay method, were 97 .4%, 100%, 96.1% and 93.7% respectively; ID50 followed by 170, 132, 125 and 110 nmol / L, ID95 was 1000, 740, 707 and 576 nmol / L; , 46.7, 45.8 and 35.4 pm1 / well. Compared with the results measured in 1981, the resistance rate showed no significant change; ID50 decreased by 22.3% (P <0.05), 26.4% (P <0.05) and 35.3% (P < 0.01). ID95 decreased by 26.0% (P <0.05), 29.3% (P <0.05) and 42.4% (P <0.01) in turn. The average inhibition decreased by 15.7% (P> 0.05), 17.3% (P <0.05) and 36.1% (P <0.01), respectively. Tip southern P. falciparum resistance to chloroquine is not stable, but decreased with the decline in drug pressure.