色霉素A_3(Toyomycin)是从Strep.griseus中获得的一种抗癌抗菌素,在结构上与光神霉素及橄榄霉素相近,它对动物P388白血病、180肉瘤腹水型、HeLa细胞,吉田肉瘤和肝癌腹水型均有作用。日本和南非的研究者曾报导,该抗菌素对人的各种实体瘤的客观疗效为9～83%。本文研究的目的是测定色霉素A_3的临床毒性并确定一个能产生一定疗效而在临床 Toyomycin is an anti-cancer antibiotic obtained from Strep.griseus and is similar in structure to mithramycin and olivine. It is effective against animal P388 leukemia, 180 ascites of sarcoma, HeLa cells, Sarcoma and liver cancer are ascites role. Researchers in Japan and South Africa have reported that the antibiotic has an objective effect of 9 to 83% on various human solid tumors. The purpose of this study is to determine the clinical toxicity of chromomycin A_3 and to determine a clinical efficacy