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为了研究银杏叶提出物对溶血性磷脂酰胆碱损伤血管内皮细胞的保护作用，本实验采用培养的猪主动脉内皮细胞为对象，观察了溶血性磷脂酰胆碱对猪主动脉内皮细胞ＰＧＩ２、ＬＤＨ、ＭＤＡ含量的影响及银杏叶提出物的拮抗作用。结果显示：溶血性磷脂酰胆碱能升高ＭＤＡ，升高ＬＤＨ，降低ＰＧＩ２；而银杏叶提出物（１０、２５、５０μｇ·ｍｌ－１）能升高ＰＧＩ２，降低ＭＤＡ、ＬＤＨ含量，且其作用与剂量相关。结论：银杏叶提出物能拮抗溶血性磷脂酰胆碱对猪主动脉内皮细胞的氧化损伤作用，且可能与促进内皮细胞ＰＧＩ２的合成、释放有关。
In order to study the protective effect of Ginkgo biloba extract on hemolytic phosphatidylcholine-induced injury of vascular endothelial cells, porcine aortic endothelial cells cultured in this experiment were used as the object. The observation of hemolytic phosphatidylcholine on porcine aortic endothelial cells PGI2 was performed. Effects of LDH and MDA content and antagonism of Ginkgo biloba extract. The results showed that: hemolytic phosphatidylcholine can increase MDA, increase LDH, reduce PGI2; while Ginkgo biloba extract (10, 25, 50 μg·ml-1) can increase PGI2, reduce MDA, LDH content, and its The effect is related to the dose. Conclusion: Ginkgo biloba extract can antagonize the oxidative damage of hemolytic phosphatidylcholine on porcine aortic endothelial cells, and may be related to the promotion of the synthesis and release of PGI2 in endothelial cells.