论文部分内容阅读
正常大鼠或吉田肉瘤大鼠腹腔注射N[C~(14)]-甲酰溶肉瘤素后第一次所排尿中,最少含有三个代謝产物。代謝物1为未变的N[C~(14)]-甲酰溶肉瘤素,其含量为尿中放射性的51.5—52.7％。代謝物2为未脫掉甲酰基的含羥基化合物排出量約为尿中放射性的20.2—23.1％。代謝物3可能是C~(14)-甲酸,排出量約为尿中放射性的9.5—12.6％。自梭形細胞肉瘤B_(22)及Krebs-2腹水癌小鼠尿中亦得到相似的結果。溶肉瘤素并非N[C~(14)]-甲酰溶肉瘤素的主要代謝产物,但并不能排除N[C~(14)]-甲酰溶肉瘤素通过溶肉瘤素轉变为溶肉瘤素羟基水解物的可能性。 N[C~(14)]-甲酰溶肉瘤素在正常动物体內的代謝在质与量上与肿瘤动物者并无不同;在对N-甲敏感瘤动物(吉田肉瘤大员、Krebs-2腹水癌小员)与不敏感瘤动物(梭形細胞肉瘤B_(22)小鼠)之間亦无明显差异。
Normal rats or Yoshida sarcoma rats after intraperitoneal injection of N [C ~ (14)] - formylcitosargin after the first urination, containing at least three metabolites. Metabolite 1 is unmodified N [C ~ (14)] -formylcysarginin, which is 51.5-52.7% of the radioactivity in urine. Metabolite 2 did not take off formyl hydroxyl-containing compounds excreted about 20.2-23.1% radioactive urine. Metabolite 3 may be C ~ (14) - formic acid, the discharge of urine radioactivity of about 9.5-12.6%. Similar results were also obtained from urine of mice with spindle cell sarcoma B_ (22) and Krebs-2 ascites. Sialylcitin is not the major metabolite of N [C ~ (14)] - formylcitrosin but does not exclude the conversion of N [C ~ (14)] - formylcitrosin to lysosarcoma The possibility of a hydroxyhydrin hydrolyzate. The metabolism of N [C ~ (14)] - formylcitrosin in normal animals is qualitatively and quantitatively similar to that of tumor-bearing animals; in the case of N-methylated tumor-bearing animals such as Krebs- 2 ascites carcinoma small staff) and insensitive tumor animal (spindle cell sarcoma B_ (22) mice) were also no significant differences.