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提高人类同种异体肾脏移植术后的长期存活率。方法 :收集我院自 1977年 10月至 1996年 5月肾脏移植的临床资料 ,以及手术切除的无功能移植肾病理标本 ,共 85例作为实验组 ;收集其相应的肾脏移植术前活检组织作为对照组。从临床病理学的角度 ,比较临床上不同的免疫抑制剂治疗组间的细胞凋亡程度 ,分析与免疫抑制剂治疗对移植肾细胞凋亡的影响。结果 :环孢霉素A(CsA) +泼尼松 (Pred) +硫唑嘌呤 (AZa)三联用药组和CsA +Pred +雷公藤多甙 (GTW )三联用药组相互与Pred +Aza二联用药组比较 ,前两组移植肾细胞凋亡程度明显轻于Pred +AZa二联用药组 (P <0 0 5 )。结论 :三联用药的免疫抑制剂治疗能减少移植肾细胞凋亡。
Improve long-term survival of human allograft kidney transplantation. Methods: The clinical data of renal transplantation in our hospital from October 1977 to May 1996 were collected, as well as the surgically resected non-functional grafted kidney pathology specimens, a total of 85 cases as experimental group; the corresponding biopsies of kidney transplantation were collected as Control group. From the clinicopathological point of view, we compared the degree of apoptosis among clinically different immunosuppressant-treated groups and analyzed the effects of immunosuppressive therapy on the apoptosis of renal allograft cells. Results: The combination of CsA + Pred + Azathione (AZa) and CsA + Pred + Tripterygium Glycosides (GTW) triple therapy groups were combined with Pred + Aza The apoptosis of renal allografts in the first two groups was significantly lower than that in Pred + AZa two groups (P <0.05). Conclusions: Triple therapy with immunosuppressive agents can reduce the apoptosis of transplanted renal cells.