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系统性红斑狼疮(SLE)病因未明、发病机制复杂。microRNA(miRNA)是一类非编码RNA分子,通过与靶基因mRNA3’UTR相互作用,使靶基因mRNA降解或翻译抑制,作为转录后基因沉默的调控分子,miRNA调控的免疫细胞发育和功能异常与自身免疫病相关。研究证实多种miRNA与SLE发病及免疫功能异常密切相关,在SLE患者中表达上调或下调并与疾病活动度相关。研究表明miRNA可能通过以下方式参与SLE发病:1型干扰素通路;异常的炎性因子分泌;DNA低甲基化和组织炎症等。本文综述了miRNA与SLE发病之间的关系及作用机制研究进展。
Systemic lupus erythematosus (SLE) etiology is unknown, the pathogenesis is complicated. MicroRNAs (miRNAs) are a class of non-coding RNA molecules that inhibit or degrade target mRNAs by interacting with the target mRNA3’UTR as regulatory molecules for post-transcriptional gene silencing. miRNAs regulate immune cell development and dysfunction and Autoimmune diseases related. Study confirmed that a variety of miRNAs and SLE pathogenesis and immune dysfunction is closely related to the expression of SLE patients with up or down regulation and disease activity related. Studies have shown that miRNAs may be involved in the pathogenesis of SLE through: type 1 interferon pathways; abnormal inflammatory cytokine secretion; DNA hypomethylation and tissue inflammation. This review summarizes the relationship between miRNAs and the pathogenesis of SLE and its mechanism of action.