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目的探讨铬铁生产工人健康损伤及血清中神经内分泌激素水平的变化,为防治铬铁生产工人健康危害提供科学的依据。方法选择贵州省黔南州某铁合金厂铬铁生产车间的5个主要工段工人129名男性为观察组,以该厂无铬和其他重金属接触史的22名健康男性为对照组,采用化学发光免疫法测定血清中催乳素(PRL)、促黄体生成素(LH)、睾酮(TST)、尿促卵泡素(TSH)及多巴胺(DA)含量水平。结果观察组和对照组作业环境空气中CrO3浓度分别为0.043~0.124和0.003~0.012mg/m3,经非参数Wilcoxon检验法检验,两组比较,差异有统计学意义(P<0.01);观察组血清中LH、TST水平均明显低于对照组,而DA水平则高于对照组,差异有统计学意义(P<0.01)。铬铁生产工人<10、10~和≥20a工龄组血清中PRL、TST、TSH、DA水平两两比较,差异均有统计学意义(P<0.01)。铬铁生产工人血清中LH水平随着接触年限增加而降低,而TSH、DA水平随着接触年限增加逐渐增高。雷蒙磨和焙烧工段工人血清中PRL、LH、TST、TSH、DA水平与冶炼工段工人比较,差异均有统计学意义(P<0.01)。结论长期从事铬铁作业工人可能会使血清中PRL、LH、TST、TSH水平下降,对生殖激素代谢产生一定的影响。
Objective To investigate the changes of health injury and serum levels of neuroendocrine hormones in ferrochrome-producing workers and provide a scientific basis for preventing and controlling the health hazards of ferrochromium producers. Methods A total of 129 males from 5 main sections of ferrochrome production workshop in a ferroalloy factory in Qiannan Prefecture of Guizhou Province were selected as the observation group. Twenty-two healthy men without chrome and other heavy metal exposure history were selected as control group. (PRL), luteinizing hormone (LH), testosterone (TST), urinary follicle stimulating hormone (TSH) and dopamine (DA) Results The concentrations of CrO3 in the working ambient air of the observation group and the control group were 0.043-0.124 and 0.003-0.012 mg / m3, respectively. The non-parametric Wilcoxon test showed that there was significant difference between the two groups (P <0.01) Serum LH and TST levels were significantly lower than the control group, while DA levels were higher than the control group, the difference was statistically significant (P <0.01). The levels of PRL, TST, TSH and DA in the ferrochromium production workers <10, 10 ~ and ≥20a working age groups were significantly different (P <0.01). The level of LH in serum of ferrochromium production workers decreased with the increase of exposure time, while the levels of TSH and DA increased gradually with the increase of exposure time. The levels of PRL, LH, TST, TSH, DA in the workers of the Raymond mill and roasting section were significantly different from those in the smelting section (P <0.01). Conclusion Long-term workers engaged in ferrochromium may reduce serum PRL, LH, TST, TSH levels, and have a certain impact on reproductive hormone metabolism.