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目的探讨2型糖尿病(type 2diabetes mellitus,T2DM)患者黄斑部视网膜厚度与尿微量白蛋白的关系。方法103例T2DM患者根据尿微量白蛋白(microalbumin,mAlb)水平分为正常组39例(mAlb≤20mg/L)、微量组33例(mAlb>20~200mg/L)和大量组31例(mAlb>200mg/L),应用高分辨率光学相干断层扫描(high definition optical coherence tomography,HD-OCT)检测3组患者185眼黄斑区以中心凹为中心直径1mm视网膜厚度、黄斑部总体积、黄斑部平均视网膜厚度,分析尿微量白蛋白水平与黄斑部视网膜厚度的关系。结果 3组黄斑区以中心凹为中心直径1mm视网膜厚度、黄斑部总体积、黄斑部平均视网膜厚度比较差异有统计学意义(P<0.05),且尿微量白蛋白水平与以上指标均呈正相关(r=0.450,P=0.007;r=0.408,P=0.000;r=0.333,P=0.003)。结论 T2DM患者黄斑部视网膜厚度与尿微量白蛋白水平有关,尿微量白蛋白可能是导致糖尿病黄斑水肿加重的危险因素之一。
Objective To investigate the relationship between macular retinal thickness and urinary albumin in type 2 diabetes mellitus (T2DM). Methods A total of 103 patients with T2DM were divided into three groups according to the level of microalbumin (mAb): 39 cases (mAlb≤20mg / L), 33 cases (mAlb> 20 ~ 200mg / L) and 31 cases > 200mg / L). High-definition optical coherence tomography (HD-OCT) was used to detect the retinal thickness of 185 macular centers, with a diameter of 1mm around the fovea. The total macular volume, The average retinal thickness, analysis of urinary albumin levels and macular retinal thickness relationship. Results There were significant differences in retinal thickness, total macular volume and macular average retinal thickness between macular area and central fovea (P <0.05), and urine microalbumin level was positively correlated with the above indexes r = 0.450, P = 0.007; r = 0.408, P = 0.000; r = 0.333, P = 0.003). Conclusion The macular retinal thickness in patients with T2DM is related to the level of urinary albumin. Urinary microalbumin may be one of the risk factors of diabetic macular edema.