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目的对益气维血片制备处方工艺进行优化改进;解决益气维血片的硬度问题。方法采用正交试验法筛选出最佳处方工艺。结果按中国药典2010年版项下有关的各项规定检查,产品质量符合要求。优选出的处方工艺条件为:50%蔗糖浆作粘合剂,5%糊精兼作粘合剂和填充剂,3%淀粉兼作崩解剂和填充剂,外加1%硬脂酸镁作润滑剂,用浅弧冲压片。结论通过正交试验法优选出的处方工艺可应用于生产。
Objective To optimize and improve the preparation and prescription of Yiqidian blood film and solve the hardness problem of Yiqiwei film. Methods Orthogonal test was used to select the best prescription. Results according to the Chinese Pharmacopoeia 2010 edition of the relevant provisions of the inspection, product quality to meet the requirements. The preferred prescription process conditions were: 50% sucrose syrup, 5% dextrin as binder and filler, 3% starch as disintegrant and filler plus 1% magnesium stearate as lubricant , With light arc stamping tablets. Conclusion Orthogonal test method can be applied to the preferential production process.