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目的:探讨肉桂酸锗对小鼠S180瘤细胞增值活性的影响。方法:建立小鼠S180移植瘤模型,应用肉桂酸锗灌胃给药后,通过免疫组织化学观察肿瘤细胞的Ki-67的表达情况。结果:观察肉桂酸锗各剂量组瘤细胞较NS组变化明显,肉桂酸锗高、中、低剂量组阳性表达率分别为70%、60%、70%,CTX组为60%,均低于NS组(90%)与NS组比较明显降低(P<0.05)。结论:肉桂酸锗能明显抑制S180移植瘤的Ki-67的表达。
Objective: To investigate the effect of germanium cinnamate on proliferation activity of S180 tumor cells in mice. Methods: The mouse S180 xenograft model was established. The expression of Ki-67 in tumor cells was observed by immunohistochemistry after gavage with germanium cinnamate. Results: The changes of tumor cells in each dose of germanium cinnamate were significantly different from those in NS group. The positive rates of high, medium and low dose of cinnamic acid were 70%, 60%, 70%, 60% in CTX group NS group (90%) was significantly lower than NS group (P <0.05). Conclusion: Germanium cinnamate can significantly inhibit the expression of Ki-67 in S180 xenografts.