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采用阻抗血流图法研究了17名健康成人服用多烯康对缺氧性肺、脑血管反应性的影响。分别于服用多烯康前后测定肺、脑血管对缺氧（10％O2＋90％N2，5min）的反应性，以缺氧时阻抗图波幅变化的百分率表示。结果表明：服用多烯康1周后，缺氧性肺血管收缩反应（HPV）由（36．3±4．5）％减弱至（24．4±4．2）％，缺氧性脑血管扩张反应（HCD）[（－19．4±6．7）％）]则翻转为收缩反应[（2．5±4.0）％]（P＜0．05），服用2周后，HPV继降至（23．8±2．8）％（P＜0．05），缺氧时脑血管仍呈收缩反应[（11．9±3．0）％]（P＜0．01）；同时，基础脑阻抗血流图波幅由（34．9±3．3）m增为（39．9±2．7）m（P＜0．05），而基础肺阻抗血流日波幅不变。提示：多烯康可抑制人体缺氧性肺脑血管反应性，为临床缺氧性肺动脉高压和肺性脑病的防治提供了一定线索。
Impedance blood flow mapping was used to study the effects of polydyneol on hypoxic pulmonary and cerebrovascular reactivity in 17 healthy adults. The reactivity of lung and cerebrovascular to hypoxia (10%O2+90%N2, 5min) was measured before and after taking polyhexol, and was expressed as the percentage change in amplitude of the impedance map during hypoxia. The results showed that after taking Doxicon for 1 week, hypoxic pulmonary vasoconstriction (HPV) attenuated from (36.3±4.5)% to (24.4±4.2)%, hypoxic cerebral vasculature The dilatation response (HCD) [(-19.4±6.7)%)] was reversed to the contractile response [(2.5±4.0)%] (P<0.05). After 2 weeks of administration, the HPV decreased. To (23.8±2.8)% (P<0.05), the cerebral blood vessels still exhibited contractile responses [(11.9±3.0)%] (P<0.01) at the time of hypoxia (P<0.01); The amplitude of basal cerebral impedance flow diagram increased from (34.9±3.3) m to (39.9±2.7) m (P<0.05), while the daily amplitude of basal pulmonary impedance blood flow did not change. It is suggested that Doxicon can inhibit the hypoxic pulmonary and cerebrovascular reactivity of the human, providing some clues for the prevention and treatment of hypoxic pulmonary hypertension and pulmonary encephalopathy.