寻找结肠直肠癌的危机因素有助于开展防治工作。在家族性腺瘤性息肉病(FAP)和遗传性非息肉病性结肠直肠癌(HNPCC),有关癌肿基因易感性已有些了解,可以从此途径探查致癌危机因素。FAP由于结肠腺瘤性息肉病(APC)基因突变而成。APC基因是一个很大的基因,含有15个外显子,编码有含2843氨基酸残基,其结构和功能已被阐明,并了解到在APC基因内突变位置与FAP的结肠和结肠外 Finding the crisis factors of colorectal cancer can help prevent and treat it. In familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), the susceptibility to cancer gene has been somewhat understood, and cancer risk factors can be explored from this approach. FAP is due to a mutation in the colon adenomatous polyposis (APC) gene. The APC gene is a large gene containing 15 exons encoded with 2843 amino acid residues whose structure and function have been elucidated, and it is known that mutations within the APC gene are located outside the colon and colon of FAP.