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目的观察双氢青蒿素-磷酸哌喹和蒿甲醚-本芴醇两种复方抗疟药对海南岛无并发症恶性疟的治疗效果。方法2005-2006年在海南省5县(市)恶性疟流行区,选择1～60岁无并发症单纯恶性疟病例107例(原虫无性体密度为1000～200000个/μl),病例随机分为2组,A组55例,口服双氢青蒿素-磷酸哌喹治疗(成人总剂量8片,1次/d,疗程为3d,首日4片),B组52例,口服蒿甲醚-本芴醇治疗(成人总剂量24片,2次/d,早晚各服4片,疗程为3d)。按照WHO体内法观察标准进行治疗、观察和随访。结果A组55例,全部完成治疗、观察和28d随访,平均退热时间为(22.35±13.26)h,平均原虫转阴时间为(34.99±12.28)h;B组52例中有51例完成治疗、观察和28d随访,平均退热时间为(20.99±11.38)h,平均原虫转阴时间为(36.45±12.60)h,两组间差异均无统计学意义(P>0.05)。28d随访两组病例均未出现复燃。个别病例在服药后出现中枢神经系统及胃肠道反应,如头痛、恶心、呕吐等,症状较轻,停药后即自行消失。未出现严重的不良反应。结论双氢青蒿素-磷酸哌喹和蒿甲醚-本芴醇两复方治疗海南岛无并发症恶性疟效果好,控制症状快,治愈率高。
Objective To observe the therapeutic effect of dihydroartemisinin - piperaquine and artemether - lumefantrine on the uncomplicated falciparum malaria in Hainan Island. Methods A total of 107 cases of simple falciparum malaria cases without complications were selected from 5 to 60 years old in Hainan province from 2005 to 2006 (the density of protozoa was 1000-200000 / μl). The cases were randomly divided into Two groups, 55 cases in group A, received oral administration of dihydroartemisinin-piperaquine phosphate therapy (total dose 8, once a day, 4 days on the first day), group B (52 cases), artemether - Benflumetol treatment (total adult dose of 24 tablets, 2 times / d, morning and evening each serving 4, treatment for 3d). In accordance with WHO in vivo observation criteria for treatment, observation and follow-up. Results All the 55 patients in group A were treated, observed and followed up for 28 days. The mean time to antipyretic was (22.35 ± 13.26) h and the mean time to parasite was (34.99 ± 12.28) h. 51 of 52 patients in group B completed the treatment (20.99 ± 11.38) h and (36.45 ± 12.60) h, respectively. There was no significant difference between the two groups (P> 0.05). 28d follow-up did not show any resurgence in both groups. Individual cases of central nervous system and gastrointestinal reactions after taking medicine, such as headache, nausea, vomiting, mild symptoms, disappear after stopping. No serious adverse reactions occurred. Conclusion Dihydroartemisinin - piperaquine and artemether - lumefantrine two complex treatment of Hainan Island without complications of falciparum malaria effective control of symptoms, the cure rate.