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目的:观察环氧化物酶2(COX-2)及上皮型粘附素(E-cadherin,E-cad)在胃癌的表达,探讨其临床意义。方法:用免疫组化法检测105例胃癌及34例正常胃黏膜中COX-2和E-cad的表达。结果:胃癌中COX-2高表达,E-cad低表达,二者在胃癌的表达均与浸润及淋巴结转移有关,胃癌中COX-2及E-cad表达呈负相关。结论:COX-2和E-cad联合检测可能对判断胃癌预后有价值。
Objective: To investigate the expression of cyclooxygenase 2 (COX-2) and E-cadherin (E-cad) in gastric cancer and to explore its clinical significance. Methods: The expressions of COX-2 and E-cad in 105 cases of gastric cancer and 34 cases of normal gastric mucosa were detected by immunohistochemistry. Results: The expression of COX-2 and low expression of E-cad in gastric cancer both correlated with the infiltration and lymph node metastasis. The expressions of COX-2 and E-cad were negatively correlated in gastric cancer. Conclusion: The combined detection of COX-2 and E-cad may be valuable in judging the prognosis of gastric cancer.