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目的:观察枸橼酸氯米芬(CC)和来曲唑(LE)两种促排卵方案用于宫腔内人工授精的疗效。方法:选取2009年3月~2013年9月我院生殖门诊因女性排卵障碍行夫精宫腔内人工授精技术助孕患者123例,随机分为2组,CC组60例,选用CC促排卵;LE组63例,选用LE促排卵。观察2组卵泡发育、妊娠率及对子宫内膜的影响。结果:CC组共完成60个治疗周期,观察到优势卵泡发育周期57个,有排卵周期52个,排卵率86.7%,单卵泡发育周期30个,单卵泡发育率50.0%。LE组共完成63个治疗周期,观察到优势卵泡发育周期59个,有排卵周期56个,排卵率88.9%,单卵泡发育周期52个,单卵泡发育率82.5%。2组排卵率差异无统计学意义(P>0.05),单卵泡发育率LE组高于CC组,差异具有显著性(P<0.05)。CC组HCG日子宫内膜厚度平均7.5±0.8mm,显著低于LE组(9.8±0.6),差异具有显著性(P<0.05)。2组妊娠率无差别(P>0.05)。结论:LE有类似CC的促排卵作用、妊娠率CC相当,但作用温和,更有利于胚胎在子宫内膜着床和妊娠维持。
OBJECTIVE: To observe the curative effect of intravitreal artificial insemination with two ovulation induction regimens of clomiphene citrate (CC) and letrozole (LE). Methods: From March 2009 to September 2013, 123 reproductive inpatients with ovulation disorder in our hospital were randomly divided into two groups (CC group, 60 cases) LE group 63 cases, the choice of LE ovulation. The follicular development, pregnancy rate and the effect on the endometrium of 2 groups were observed. Results: A total of 60 treatment cycles were completed in CC group. 57 dominant ovarian follicles were observed, including 52 ovulation cycles, ovulation rate 86.7%, single follicle development cycle 30 and single follicle development rate 50.0%. LE group completed a total of 63 treatment cycles, observed the dominant follicle development cycle 59, ovulation cycle 56, ovulation rate 88.9%, single follicle development cycle 52, single follicle development rate of 82.5%. There was no significant difference in ovulation rate between the two groups (P> 0.05). The single follicle development rate in LE group was higher than that in CC group, the difference was significant (P <0.05). The endometrial thickness of HCG group in CC group was 7.5 ± 0.8 mm on average, which was significantly lower than that in LE group (9.8 ± 0.6), the difference was significant (P <0.05). No difference in pregnancy rate between the two groups (P> 0.05). Conclusion: LE has a similar role of ovulation promoting ovulation CC, pregnancy rate CC quite, but the role of mild, more conducive to embryo implantation in the endometrium and pregnancy maintenance.