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目的探讨顺铂(DDP)诱导消化系统迟发性反应机制及中药丹参(SM)的拮抗作用。方法 30只豚鼠随机分为正常对照组、DDP组、丹参+顺铂(SM+DDP)组,观察用药前后体质量变化、胃电图(EGG)改变,并进行胃、肠组织超微结构观察。结果 DDP组豚鼠体质量明显减轻(P<0.05),透射电镜发现胃肠组织细胞破坏严重,而SM+DDP组豚鼠各方面情况要好于DDP组,同时透射电镜表现有大量吞噬体存在。各组胃电图显示DDP组振幅增加、频率增快(P<0.05),而SM+DDP组EGG与正常对照组比较无明显变化。结论顺铂诱导胃肠道迟发性反应的发生可能与胃肠组织黏膜屏障功能受损,引起致病菌侵害有关,而丹参能够清除致病菌,从而具有一定的拮抗作用。
Objective To investigate the mechanism of delayed response of digestive system induced by cisplatin (DDP) and the antagonism of traditional Chinese medicine Salvia miltiorrhiza (SM). Methods Thirty guinea pigs were randomly divided into normal control group, DDP group and SM + DDP group. The changes of body weight and EGG were observed before and after treatment. The ultrastructure of stomach and intestine was observed . Results The body weight of guinea pigs in DDP group was significantly reduced (P <0.05). The transmission electron microscopy showed that the cells in gastrointestinal tract were damaged severely. In the SM + DDP group, the guinea pigs were better than the DDP group in all respects. Electroencephalogram in each group showed that the amplitude of DDP group was increased and the frequency was increased (P <0.05), while the EGG of SM + DDP group had no significant change compared with the normal control group. Conclusion DDP induced gastrointestinal tract delayed response may be impaired in gastrointestinal mucosal barrier function, causing pathogen damage, while Salvia can clear pathogenic bacteria, which has a certain antagonistic effect.