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目的研究血清与粪便S100A12蛋白在新生儿坏死性小肠结肠炎(NEC)中的诊断及临床效果。方法 40例新生儿坏死性小肠结肠炎患儿为观察组,同时选取同期住院的40例黄疸新生儿为对照组,分别检测比较两组的血清与粪便S100A12蛋白水平,分析血清与粪便中S100A12蛋白与疾病进展的关系。结果对照组血清及粪便S100A12蛋白检出率均为7.5%(3/40),观察组血清S100A12蛋白Ⅰ期检出率为85.7%(12/14),极期检出率为90.5%(19/21),恢复期检出率为60.0%(3/5);观察组粪便S100A12蛋白Ⅰ期检出率为78.6%(11/14),极期检出率为85.7%(18/21),恢复期检出率为60.0%(3/5);观察组患儿极期的血清及粪便S100A12蛋白检出率明显高于恢复期检测率(P<0.05);Ⅰ期的血清及粪便S100A12蛋白检出率明显高于恢复期检测率(P<0.05);观察组血清与粪便S100A12蛋白检出率明显高于对照组(P<0.05)。结论通过血清与粪便S100A12蛋白检出率观察,可以早期诊断出新生儿坏死性小肠结肠炎。
Objective To study the diagnosis and clinical effect of S100A12 protein in serum and stool in neonatal necrotizing enterocolitis (NEC). Methods Forty neonates with neonatal necrotizing enterocolitis were selected as the observation group and 40 neonates with jaundice in the same period were selected as the control group. The levels of S100A12 protein in serum and faeces were detected and compared between the two groups. The S100A12 protein Relationship with disease progression. Results The detection rates of S100A12 protein in serum and feces were 7.5% (3/40) in control group. The detection rate of S100A12 protein in observation group was 85.7% (12/14) and 90.5% / 21), the recovery rate was 60.0% (3/5). The detection rate of stool S100A12 in the observation group was 78.6% (11/14), and the positive detection rate was 85.7% (18/21) , And the recovery rate was 60.0% (3/5). The detection rate of serum S100A12 in the observation group was significantly higher than that in recovery period (P <0.05). The serum and fecal S100A12 in stage Ⅰ The detection rate of S100A12 protein in serum and feces was significantly higher than that in control group (P <0.05). Conclusion The detection rate of S100A12 protein in serum and feces can be used to diagnose neonatal necrotizing enterocolitis early.