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目的探讨甘草酸二铵胶囊联合替比夫定治疗慢性乙型病毒性肝炎的治疗效果。方法将60例病毒性肝炎患者随机分成两组。治疗组采用替比夫定联合甘草酸二铵胶囊口服治疗;对照组采用替比夫定单药抗病毒治疗。结果两组都能有效缓解病毒性肝炎的症状,可有效减少乏力、纳差、腹胀等症状,组间对比无统计学意义(P>0.05),于治疗期间服用甘草酸二铵的病毒性肝炎患者未出现严重的不良反应。两组肝生化指标对比组间差异显著(P<0.05);两组均能有效抑制乙型肝炎病毒复制,HBV-DNA均显著下降,组间对比无显著差异(P>0.05)。结论甘草酸二铵胶囊联合替比夫定治疗慢性乙型病毒性肝炎较替比夫定单药治疗抗炎保肝效果更好,但两组均能有效抑制乙型肝炎病毒复制,无显著差异。
Objective To investigate the therapeutic effect of diammonium glycyrrhizinate combined with telbivudine in the treatment of chronic hepatitis B virus. Methods Sixty patients with viral hepatitis were randomly divided into two groups. The treatment group was treated with telbivudine and diammonium glycyrrhizinate orally. The control group was treated with telbivudine single-drug anti-virus. Results Both groups were able to effectively relieve the symptoms of viral hepatitis, which could effectively reduce symptoms such as fatigue, anorexia, bloating and other symptoms. There was no significant difference between the two groups (P> 0.05). During the treatment period, viral hepatitis with diammonium glycyrrhizinate The patient did not have a serious adverse reaction. There was significant difference between the two groups in biochemical indexes (P <0.05). Both groups could effectively inhibit the replication of hepatitis B virus (HBV) and the HBV-DNA levels were significantly decreased. There was no significant difference between the two groups (P> 0.05). Conclusion The combination of diammonium glycyrrhizinate and telbivudine in the treatment of chronic hepatitis B is more effective than the anti-inflammatory and hepatoprotective effects of telbivudine alone. However, both groups can effectively inhibit the replication of hepatitis B virus with no significant difference.