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目的研究用非手术多学科综合手段治疗中晚期肺癌,探讨如何有机地将这些治疗手段结合起来,延长病人生存期。方法将接受VCMB方案化疗并同时行放疗、中医中药、生物治疗的中晚期肺癌患者共42例纳入治疗组,将接受放疗+化疗或单纯行放疗或化疗而未行中医中药、生物治疗的中晚期肺癌患者共33例纳入对照组。随访5个月～6年。观察毒性反应、首次治疗缓解程度、年生存率,并进行2组之间的比较,分析可能影响疗效的诸因素,行生存分析+多元Cox回归。结果首次治疗后2组缓解程度比较,差异有统计学意义(χ2=12.242,P=0.007);各年生存率2组比较差异有统计学意义(P均<0.05);治疗组和对照组中位生存时间分别为20.52个月和11.64个月。肿瘤部位、缓解情况、卡氏评分、治疗方法为影响生存时间的主要因素。结论多学科综合治疗方案治疗中晚期肺癌,对延长病人生存期和提高生存质量有初步成效。
Objective To study the use of non-surgical multi-disciplinary comprehensive treatment of advanced lung cancer, to explore how to organically combine these treatments to extend the patient’s survival. Methods A total of 42 patients with advanced lung cancer who underwent VCMB regimen and received concurrent radiotherapy were enrolled in the treatment group. Patients who received radiotherapy + chemotherapy or simple radiotherapy or chemotherapy without advanced Chinese medicine and biotherapy A total of 33 patients with lung cancer were included in the control group. Follow-up of 5 months to 6 years. To observe the toxicity, the degree of first-aid treatment and the annual survival rate, and to compare the two groups, analyze the factors that may affect the efficacy, survival analysis + multivariate Cox regression. Results There was significant difference in the degree of remission between the two groups after the first treatment (χ2 = 12.242, P = 0.007). There was significant difference in the survival rates between the two groups (P <0.05) The median survival time was 20.52 months and 11.64 months respectively. Tumor site, mitigation, Karnofsky score, treatment is the main factor affecting the survival time. Conclusions Multidisciplinary comprehensive treatment regimen for the treatment of advanced lung cancer has initial effect on prolonging survival and improving quality of life.