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目的:考察柔红霉素和胰岛素配伍在葡萄糖溶液中的稳定性。方法:观察及测定柔红霉素-胰岛素-5%葡萄糖配伍后分别在室温避光和室温不避光条件下放置24 h内外观、pH变化及不溶性微粒,采用高效液相色谱法测定配伍液中柔红霉素、胰岛素含量的变化。结果:配伍液在24 h内无浑浊、沉淀、气体产生,颜色、pH、不溶性微粒数等无明显变化,柔红霉素、胰岛素含量无明显变化。结论:在试验条件下,柔红霉素、胰岛素在5%的葡萄糖注射液中配伍稳定。
Objective: To investigate the stability of daunorubicin and insulin compatibility in glucose solution. Methods: After observing and measuring the compatibility of daunorubicin-insulin-5% glucose, the appearance, pH and insoluble particles within 24 h were stored at room temperature under dark and at room temperature without light. The compatibility of the solutions was determined by high performance liquid chromatography Middle daunorubicin, insulin content changes. Results: No obvious turbidity, precipitation, gas production, color, pH and insoluble particles were observed in the compatibility solution within 24 h. The content of daunorubicin and insulin did not change significantly. Conclusion: Under the experimental conditions, daunorubicin and insulin are stable in 5% glucose injection.