论文部分内容阅读
欧洲完成的三项试验证实重组合组织型纤溶酶原激活剂(rt-PA)治疗急性心肌梗塞是安全有效的.本文旨在确定rt-PA 的治疗效果和那些因素有关。方法:第一组129例和安慰组对比,第二组129例和链激酶组对比,第三组为再次心肌梗塞组123例。选择标准相同.患者先接受5000Iu 肝素;随即静脉滴注 rt-PA(g-11021 Gen entech Inc)。前二组剂量为0.75mg/kg 体重,总量不超过60mg;第三组总量为40mg,于90min 内静脉滴入。病例剔除标准差别在于:前二组为既往心肌梗塞史,第三组为本次急性心肌梗塞和既往梗塞部位不同者。治疗均在发病6h 内开始(第三组4h 内)。治疗90min时,作冠状动脉造影。梗塞区内无血管显影,不管有无侧枝循环定为完全阻塞。三个心动周期未能完全充盈定为部分阻塞。狭窄大于90%,但三个心动周期能满意充盈者定为通畅。
Three trials completed in Europe confirmed that recombinant tissue-type plasminogen activator (rt-PA) is safe and effective for the treatment of acute myocardial infarction.This paper aims to determine the therapeutic effect of rt-PA in relation to those factors. Methods: The first group of 129 cases compared with the comfort group, the second group of 129 cases compared with streptokinase group, the third group was again myocardial infarction group of 123 cases. The selection criteria were the same, and patients received 5000 Iu heparin first; then rt-PA (g-11021 Gen entech Inc) was given intravenously. The former two doses of 0.75mg / kg body weight, the total does not exceed 60mg; the third group of 40mg, within 90min intravenous infusion. The difference between the standard cases of culling is that the first two groups are the history of previous myocardial infarction, and the third group is the patients with different acute myocardial infarction and past infarction. Treatment within 6h onset (the third group 4h). 90min treatment, coronary angiography. No infarction area of vascular imaging, regardless of whether the collateral circulation was completely blocked. Three cardiac cycles were not fully filled as partial obstruction. Stenosis is greater than 90%, but the three cardiac cycles can be satisfied with filling those who are unobstructed.