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Dickkopf-1(DKK-1)为Dickkopfs(DKKs)家族的一员,属于一种分泌型糖蛋白,作为Wnt/β-连环蛋白(β-catenin)经典信号传导通路的拮抗剂而受到关注。大量实验证明,DKK-1在诱导肿瘤细胞凋亡,调控肿瘤细胞的骨转移方面以及某些肿瘤细胞的浸润和侵袭方面发挥重要作用。就DKK-1的分子生物学特点、在肿瘤细胞中的信号传导途径和功能,及其在妇科肿瘤中的作用做文献综述。
Dickkopf-1 (DKK-1), a member of the Dickkopfs (DKKs) family, is a secreted glycoprotein that has drawn attention as an antagonist of the classical signaling pathway of the Wnt / β-catenin. A large number of experiments have shown that DKK-1 plays an important role in inducing tumor cell apoptosis, regulating bone metastasis of tumor cells and infiltration and invasion of some tumor cells. The molecular biology of DKK-1, signal transduction pathways and functions in tumor cells, and their roles in gynecological tumors are reviewed.