论文部分内容阅读
目的:观察低剂量羟基喜树碱(HCPT)联合低剂量FLP方案治疗晚期消化系肿瘤的疗效和毒副作用。方法:37例晚期消化系肿瘤患者,予以HCPT5mg/d,连用12天,CF100mg/d,静滴2小时,5Fu300mg/d,持续静脉灌注(加入Baxter泵),连用14天,PDD8mg/d,静点2小时,第1～5天,第8～14天。结果:37例患者均可评价疗效,其中CR2例(5.4%),PR20例(54.1%),SD14例(37.8%),PD1例(2.7%),总有效率(CR+PR)为59.5%。主要毒副作用为消化道反应、静脉炎和轻度骨髓抑制。结论:应用低剂量HCPT联合低剂量FLP方案治疗晚期消化系肿瘤有效率高,毒性反应小,且能明显改善患者生活质量。
Objective: To observe the curative effect and toxicity of low dose of hydroxycamptothecin (HCPT) combined with low dose FLP regimen in patients with advanced digestive system tumors. Methods: Thirty-seven patients with advanced gastrointestinal cancer were treated with HCPT 5 mg / d for 12 days, CF 100 mg / d, intravenous drip for 2 hours, and 5Fu 300 mg / d for continuous intravenous infusion (Baxter pump) for 14 days, PDD 8 mg / Point 2 hours, the first 1 to 5 days, the first 8 to 14 days. Results: All of the 37 patients were evaluated by CR2 (5.4%), PR20 (54.1%), SD14 (37.8%), PD1 (2.7%) and total effective rate . The main side effects of gastrointestinal reactions, phlebitis and mild myelosuppression. Conclusion: The combination of low dose HCPT and low dose FLP regimen has the advantages of high efficiency, less toxic reaction and better quality of life in patients with advanced digestive system tumors.