前言含药颗粒或微丸可采用聚合物包衣来控制药物释放的开始时间和释放率。丙烯酸盐与甲基丙烯酸酯共聚物在这方面已有应用。共聚物不溶于水,因此其衣膜只能从有机溶剂中沉积形成,但有机溶剂价格高并在一定条件下易燃。最近研究表明,向聚合物的乙醇溶液中加入超量水(通过凝聚)易形成这些共 Introduction Pellets or pellets with a drug may be coated with a polymer to control the onset and release rate of drug release. Acrylates and methacrylate copolymers have been used in this area. Copolymers are insoluble in water, so their film can only be deposited from organic solvents, but the organic solvents are expensive and flammable under certain conditions. Recent studies have shown that adding excess water to the polymer in ethanol (by agglomeration) readily forms these