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目的研究DKK-1在骨肉瘤中的表达情况,探讨其与临床病理及预后的关系。方法S-P免疫组织化学染色法对74例骨肉瘤DKK-1蛋白的表达进行检测,并对其与骨肉瘤临床病理及预后的关系进行统计学分析。结果74例骨肉瘤标本中58例为阳性,总阳性率为78.4%(58/74)。DKK-1的表达在不同年龄、性别、骨肉瘤亚型中无显著性差异。Enneking分期Ⅰ-ⅡA与ⅡB-Ⅲ之间,肿瘤DKK-1表达率有显著性差异(P<0.05)。结论DKK-1在骨肉瘤组织中有较高比例的表达,并与肿瘤的外科分期密切相关。
Objective To study the expression of DKK-1 in osteosarcoma and to explore its relationship with clinicopathological features and prognosis. Methods The expression of DKK-1 protein in 74 cases of osteosarcoma was detected by S-P immunohistochemical staining. The relationship between the expression of DKK-1 protein and the clinicopathological features and prognosis of osteosarcoma was statistically analyzed. Results Of the 74 osteosarcoma specimens, 58 were positive and the total positive rate was 78.4% (58/74). DKK-1 expression in different age, gender, osteosarcoma subtype no significant difference. Enneking stage Ⅰ-ⅡA and ⅡB-Ⅲ between the tumor DKK-1 expression was significantly different (P <0.05). Conclusions DKK-1 is highly expressed in osteosarcoma and closely related to the surgical stage of the tumor.