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右旋糖酐由于分子量不同,在临床上具有不同的作用.中分子右旋糖酐,有良好的扩充血容量的作用,主要用于防治各种休克,如出血性休克、创伤性休克、烧伤休克及手术休克等,战时需用量大,平时使用量则较小.低分子及小分子右旋糖酐,具有改善血液微循环和使红细胞解聚等作用,常用于治疗血栓闭塞性脉管炎、中毒性休克、中毒性痢疾以及某些心血管疾患等.但是原生产工艺生产低、小分子右旋糖酐的产率低,与平时需要量大是一个矛盾.近几年来低、小分子右旋糖酐在临床上广泛用于治疗冠心病后,供求矛盾更加突出.为满足临床需要,我们于1974年底开始研究改进低、小分子右旋糖酐生产工艺的工作.通过几年来的生产实践
Dextran has different clinical effects due to different molecular weights.Metal dextran has a good expansion of blood volume, which is mainly used for prevention and treatment of various shocks such as hemorrhagic shock, traumatic shock, burn shock and surgical shock, Wartime need a large amount, usually the amount used is smaller.Demolecular and small molecule dextran, has the effect of improving blood microcirculation and erythrocyte depolymerization, commonly used in the treatment of thromboangiitis obliterans, toxic shock, toxic dysentery And some cardiovascular diseases, etc. However, the low production of low-molecular-weight dextran in the original production process is contradictory to the large amount of usual dextran.In recent years, low-molecular dextran has been widely used clinically for the treatment of coronary heart disease , The contradiction between supply and demand is more prominent.In order to meet the clinical needs, we began to study the improvement of low and small molecule dextran production process at the end of 1974. Through years of production practice