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目的:探讨多囊卵巢综合征患者不同促排卵方案的疗效。方法:选择2014年3月4日~2016年3月4日在我院就诊78例多囊卵巢综合征患者,把78例患者随机分为三组:氯米芬(CC)组,尿促素(HMG)组,来曲唑(LZ)组。所有患者均于月经第5天或黄体酮撤退性出血的第5天,拟行促排卵治疗并指导同房。观察三组患者的排卵率及周期妊娠率。结果:三组的排卵率无显著性差异(P>0.05);周期妊娠率:来曲唑组与尿促素组均高于氯米芬组(P<0.01),来曲唑组与尿促素组周期妊娠率无显著性差异(P>0.05),子宫内膜厚度来曲唑组厚于氯米芬组,但中、重卵巢过度刺激综合征发生率来曲唑组低于尿促素组。结论:来曲唑用于多囊卵巢综合征的不孕症妇女,具有良好的排卵率及妊娠率,又能减少卵巢过度刺激综合征发生的风险。
Objective: To investigate the curative effect of ovulation induction in patients with polycystic ovary syndrome. Methods: From March 4, 2014 to March 4, 2016, 78 patients with polycystic ovary syndrome were treated in our hospital. 78 patients were randomly divided into three groups: clomiphene citrate (CC) group, (HMG) group, letrozole (LZ) group. All patients on the 5th day of menstruation or progesterone withdrawal bleeding on the 5th day, to be planned ovulation induction treatment and guidance of the same room. The ovulation rate and cycle pregnancy rate of the three groups were observed. Results: There was no significant difference in ovulation rate between the three groups (P> 0.05). The rate of pregnancy was significantly higher in the letrozole group and the urinary factor group than in the clomiphene group (P <0.01) There was no significant difference in the pregnancy rate between the two groups (P> 0.05). Letrozole group was thicker than clomiphene group in the endometrium, but the incidence of over-stimulation syndrome in the letrozole group was lower than that in the urine group. Conclusion: Letrozole for infertility women with polycystic ovary syndrome has a good ovulation rate and pregnancy rate, but also reduce the risk of ovarian hyperstimulation syndrome.