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目的 探讨抗甲状腺药物(ATD)对甲状腺摄1 31 I率的影响及其对1 31 I治疗甲亢疗效的影响。方法 经临床症状、体格检查及血清学检查确诊的甲亢患者,分为未服ATD组、服ATD停药>1月组和服ATD停药<1月组。所有患者满足甲状腺摄1 31 I试验要求后作4 h、6 h和2 4 h摄1 31 I率测定,1 31 I治疗采用个性化方案。治疗后3月、6月复查并评价治疗效果。结果 3组患者间甲状腺摄1 31 I率无显著性差异(P>0 .0 5 ) ;但高峰前移发生率在停药<1月组明显高于其它两组(P<0 .0 5 )。总的1 31 I一次治愈率达75 .3% ,但治疗效果在停药<1月组明显低于其他两组(P<0 .0 5 )。结论 ATD对甲状腺摄1 31 I率在停药时间较短时有影响,且主要影响1 31 I的有效半衰期,进一步影响1 31I治疗甲亢的疗效。
Objective To investigate the effect of antithyroid drug (ATD) on thyroid uptake of 131I and its effect on the treatment of hyperthyroidism by 131I. Methods Patients with hyperthyroidism diagnosed by clinical symptoms, physical examinations and serological tests were divided into two groups: ATD group without ATD, ATD withdrawal> January group and ATD withdrawal group 0.05), but the incidence of peak uptake in the withdrawal group was significantly higher than that in the other two groups (P <0.05) ). The total cure rate of 131 I was 75.3% at one time, but the therapeutic effect was significantly lower in the withdrawal group than in the other two groups (P <0.05). Conclusions ATD has a significant effect on the thyroid uptake rate of 131 I in the short withdrawal time and mainly affects the effective half-life of 131 I, further affecting the efficacy of 131 I in the treatment of hyperthyroidism.