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目的:观察屈螺酮炔雌醇片对人工流产术后的阴道出血及子宫内膜黏膜修复的疗效和安全性。方法:140例行人工流产术的早期妊娠患者随机分为观察组与对照组。两组患者均在静脉麻醉下行人工流产术,术后常规予以口服抗菌药预防感染。观察组在此基础上予屈螺酮炔雌醇片1片,po qd,连服3周,停药1周后开始第2周期,连用3个周期。观察两组患者阴道出血时间、阴道出血量、首次月经复潮时间、术后3周子宫内膜厚度,以及治疗期间的药品不良反应。结果:观察组患者术后阴道流血时间、阴道流血量和首次月经复潮时间明显短于对照组(P<0.05),术后3周子宫内膜厚度恢复明显优于对照组(P<0.05)。治疗期间,观察组出现胃部不适3例,症状较轻,对照组未发生明显药品不良反应。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:人工流产术后口服屈螺酮炔雌醇有利于子宫内膜的修复,减少阴道出血量,缩短阴道流血时间,有利于患者月经周期的恢复,且安全性好。
Objective: To observe the efficacy and safety of drospirenone ethinyl estradiol tablets for vaginal bleeding and endometrial mucosa repair after induced abortion. Methods: 140 cases of early pregnancy induced abortion were randomly divided into observation group and control group. Both groups underwent artificial abortion under intravenous anesthesia and were routinely given oral antibacterials to prevent infection. Observation group on the basis of drospirenone ethinyl estradiol tablets 1, po qd, even for 3 weeks, 1 week after the start of the second cycle, once every 3 cycles. Vaginal bleeding time, volume of vaginal bleeding, first menstruation tonic time, endometrial thickness at 3 weeks postoperatively, and adverse drug reactions during the treatment were observed. Results: The time of postoperative vaginal bleeding, vaginal bleeding and the time of the first menstrual cycle were significantly shorter in the observation group than in the control group (P <0.05), and the recovery of endometrial thickness at 3 weeks was significantly better than that of the control group (P <0.05) . During the treatment period, the observation group had 3 cases of stomach discomfort, the symptoms were mild, and the control group did not have obvious adverse drug reactions. The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). CONCLUSION: Oral administration of drospirenone ethinyl estradiol after end-to-end abortion is beneficial to the repair of endometrium, reducing the amount of vaginal bleeding and shortening the vaginal bleeding time, which is in favor of the recovery of menstrual cycle and is safe.