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目的观察T1DM患者血清内脂素(visfatin)水平的变化,探讨其与T1DM患者糖脂代谢的相关性。方法采用ELISA测定31例T1DM患者、33例T2DM患者和30名健康者(NC)血清visfatin水平,同时测定FPG、FIns、TG、TC、HDL-C、LDL-C及HbA_1 c,计算WHR、BMI及胰岛β细胞功能指数(HOMA-β3)。结果 T1DM组血清visfatin水平较NC组和T2DM组减低,且T2DM组高于NC组[(96.4±52.0)vs(138.3±66.9)vs(205.7±82.2)pg/ml,P<0.05]。T1DM组血清visfatin水平与BMI、WHR、FIns、HOMA-3呈正相关(r=0.351、0.591、0.528、0.557,P均<0.01)。多元逐步回归分析显示,WHR、HOMA-β是T1DM患者visfatin水平的独立相关因素。结论 T1DM患者血清visfatin水平降低可能与WHR和HOMA-β降低有关。
Objective To observe the change of serum visfatin level in T1DM patients and explore its correlation with the level of glucose and lipid metabolism in T1DM patients. Methods Serum visfatin levels were measured in 31 cases of T1DM, 33 cases of T2DM and 30 healthy persons by ELISA. The levels of FPG, FIns, TG, TC, HDL-C, LDL-C and HbA 1 c were also measured. And pancreatic β-cell function index (HOMA-β3). Results Serum visfatin levels in T1DM group were significantly lower than those in NC group and T2DM group (P <0.05). The level of visfatin in T1DM group was positively correlated with BMI, WHR, FIns and HOMA-3 (r = 0.351,0.591,0.528,0.557, P <0.01). Multivariate stepwise regression analysis showed that WHR and HOMA-β were independently associated with visfatin levels in T1DM patients. Conclusion The decrease of serum visfatin in T1DM patients may be related to the decrease of WHR and HOMA-β.