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肿瘤细胞的内在耐药性是化疗失败的重要原因，也是影响肿瘤预后的重要因素，其机理尚不清楚。在对表鬼臼毒素（ｖｅｐｅｓｉｄ，ＶＰ－１６）具有耐药性的人类口腔鳞癌ＫＢ细胞株中，发现拓扑异构酶１１（Ｔｌｌ）表达水平的改变。Ｔｌｌ是真核细胞生存的关键酶，参与ＤＮＡ代
The intrinsic drug resistance of tumor cells is an important cause of chemotherapy failure and an important factor affecting the prognosis of tumors. The mechanism is not yet clear. In human oral squamous cell carcinoma KB cell strains resistant to vepesid (VP-16), the expression level of topoisomerase 11 (Tll) was found to change. Tll is a key enzyme for the survival of eukaryotic cells involved in DNA generation