论文部分内容阅读
烯丙尼定(Alinidine,简称ALI)是一种咪唑啉衍生物,为特异性心动减缓药,其主要作用是选择性抑制窦房结的起搏细胞。本文采用开放试验评价ALI对慢性充血性心衰(CCHF)病人的血流动力学影响。 10例CCHFⅡ～Ⅲ级病人,均为窦性心律,所有病人先在心电图监护下静注ALI45mg,随后以每小时10mg的速度静脉滴注本品。给药前、给药后1.5和3小时分别进行静息和运动时的放射性核素心室造影。结果给药后,静息和运动时的左室射血分数、每搏容量和舒张末容量指数与给药
Alinidine (ALI) is an imidazoline derivative that is a specific antihypertensive drug whose main effect is the selective inhibition of pacemaker cells in the sinoatrial node. This article uses an open trial to evaluate the hemodynamic effects of ALI on patients with chronic congestive heart failure (CCHF). 10 cases of CCHF Ⅱ ~ Ⅲ-level patients, all sinus rhythm, all patients with intravenous ALI45mg under ECG monitoring, followed by intravenous infusion of the product at a rate of 10mg per hour. Before administration, radionuclide ventriculography was performed at rest and during exercise at 1.5 and 3 hours after dosing. Results After administration, left ventricular ejection fraction, stroke volume and end-diastolic volume index