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p16多肿瘤抑制基因(MTS-1,CDKN2)在人类多种肿瘤和癌细胞系出现缺失和突变,预示其在肿瘤发生、发展中起重要作用。对头颈部鳞癌、癌前病变及癌细胞系的实验中,均发现p16基因发生高频率的杂合性丢失(LOH),推测该基因的丢失在头颈癌发生早期就已出现,与头颈癌的发生密切相关。深入研究p16基因不仅有助于阐明头颈肿瘤细胞周期的分子调节机理,而且在肿瘤的早期辅助诊断,预后判断和基因治疗中具有重要的意义。本文就p16基因与头颈部癌发生、发展关系的研究现状及前景作了综述。
The p16 multiple tumor suppressor genes (MTS-1, CDKN2) in many human tumors and cancer cell lines appear deletions and mutations, indicating that it plays an important role in tumorigenesis and development. In the experiments of head and neck squamous cell carcinoma, precancerous lesions, and cancer cell lines, the high frequency of loss of heterozygosity (LOH) was found in the p16 gene. It was hypothesized that the loss of this gene occurred early in the development of head and neck cancer, with head and neck cancers. The occurrence is closely related. In-depth study of p16 gene not only helps elucidate the molecular regulation mechanism of head and neck tumor cell cycle, but also has important significance in the early diagnosis of tumor, prognosis and gene therapy. This article reviews the current status and prospects of the relationship between the p16 gene and the occurrence and development of head and neck cancer.