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目的 探讨严重急性呼吸综合征 (SARS)康复者特殊献浆健康检查标准。方法 对志愿献浆的SARS康复者进行诊断确认、健康鉴定、常规献血前检查、血浆SARS冠状病毒荧光PCR检测及抗体ELISA检测。结果 4 5名志愿者中有 19名因健康状况或近期献血、或SARS抗体筛查阴性或其他原因未单采血浆 ,其余 2 6名分别每人单采血浆 2 0 0ml(1例为月经结束第 2天 ,1例ALT异常 ,2例Hb偏低 ,1例胸片轻度异常 ,4例肺功能轻度异常和 1例中度限制性通气功能障碍 ) ,30名志愿者血样SARS冠状病毒抗体检测 (稀释 8倍以上 )仍呈阳性反应 ;SARS病毒荧光PCR检测均为阴性。结论 对特殊志愿献浆的SARS康复者 ,部分健康检查标准可酌情放宽 ,是否存在SARS冠状病毒抗体是采浆与否的重要参考指标 ,该抗体可能因具有中和病毒的作用而用于SARS的临床治疗
Objective To investigate the special screening criteria for health screening of patients with severe acute respiratory syndrome (SARS). Methods The diagnosis, identification, routine pre-donation blood test, plasma SARS coronavirus PCR and antibody ELISA were carried out on the volunteers who were sacrificed. Results Of the 45 volunteers, 19 were not healthy due to health status or recent blood donation or were negative for SARS antibody screening or other reasons. The other 26 were apheresis 200 ml each (1 case was end of menstruation On the second day, one case had abnormal ALT, two cases had low Hb, one case had mild chest abnormality, four cases had mild pulmonary dysfunction and one case had moderate restrictive ventilation dysfunction. Thirty volunteers’ blood samples of SARS coronavirus Antibody detection (diluted more than 8 times) still positive reaction; SARS virus fluorescence PCR test were negative. CONCLUSIONS: Some SARS-excercising patients who voluntarily volunteer for special volunteers may relax some of their health check-up criteria. Whether SARS-CoV antibody is an important reference for plasma pick-up or not may exist in this study. The antibody may be used for SARS by neutralizing virus Clinical treatment