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目的评价北京地区老年人群幽门螺杆菌(Hp)及其亚型(CagA,VacA)感染的血清流行率及影响因素。方法采用整群随机抽样的方法人户问卷调查了北京不同地区(城区、郊区、山区) 60岁及以上的老年人2006名,应用免疫印迹法测定血清Hp CagA、VacA和Ureas抗体。结果老年人群总的Hp感染率为83.4%,Ⅰ型Hp菌株感染率为56.0%;郊区和城区高于山区(P<0.001);以体力劳动为主的老年人Hp菌株的感染率高于以脑力劳动为主的老年人(P<0.05);以素食为主的老年人Ⅰ型Hp菌株感染率显著高于以高蛋白饮食为主的老年人(P<0.001)。结论Hp在北京地区老年人群中存在着较高的血清流行率,以Ⅰ型Hp菌株感染为主,其亚型分布在年龄、地区和饮食习惯上存在显著差异。
Objective To evaluate the seroprevalence and influential factors of Helicobacter pylori (Hp) and its subtype (CagA, VacA) infection in elderly population in Beijing. Methods A total of 2006 randomized population sampling questionnaires were used to investigate the prevalence of Hp CagA, VacA and Ureas antibodies in different regions of Beijing (urban, suburban and mountainous areas) aged 60 years and above. Results The overall prevalence of Hp infection in elderly population was 83.4%, the infection rate of type Ⅰ Hp strains was 56.0%, that in suburban and urban areas was higher than that in mountainous areas (P <0.001), and that of Hp strains mainly in manual labor was higher than that in (P <0.05). The infection rate of type Ⅰ Hp strains in vegetarian predominant was significantly higher than that of the elderly with high protein diet (P <0.001). Conclusions There is a high seroprevalence of Hp in the elderly population in Beijing. The prevalence of Hp infection is mainly of type I Hp, and the subtypes of Hp are significantly different in age, region and diet.