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[目的]探讨阿托伐他汀对非酒精性脂肪性肝炎(NASH)患者肝功能和血清超敏C反应蛋白(hs-CRP)、白介素(IL)-6和IL-10的影响。[方法]选取NASH患者90例,随机分为对照组和观察组,每组45例。2组患者予以控制饮食、适当体育锻炼及常规内科保肝等治疗。观察组患者加用阿伐他汀片20 mg/次,1次/d,连用16周。对照组除不使用阿伐他汀片外余治疗与观察组相同。观察2组患者治疗前后肝功能指标和血清hs-CRP、IL-6和IL-10水平的变化。[结果]治疗16周后,2组患者ALT和GGT水平均较前明显下降(P<0.05或P<0.01),且观察组下降值较对照组更明显(P<0.05);同时2组血清hs-CRP、IL-6水平均较前明显下降,IL-10水平较前明显上升(P<0.05或P<0.01),且观察组变化幅度较对照组更明显(P<0.05)。[结论]阿托伐他汀辅助治疗NASH效果良好,能明显改善肝功能,并能降低hs-CRP和IL-6水平,升高抗炎性因子IL-10水平,从而纠正促炎性因子与抗炎性因子比例紊乱,抑制肝内炎症免疫性损伤达到治疗目的。
[Objective] To investigate the effects of atorvastatin on liver function, serum hs-CRP, IL-6 and IL-10 in patients with non-alcoholic steatohepatitis (NASH). [Methods] 90 patients with NASH were randomly divided into control group and observation group, with 45 cases in each group. 2 groups of patients to be controlled diet, appropriate physical exercise and routine medical treatment of liver and other treatment. Patients in the observation group were treated with atorvastatin 20 mg once daily for 16 weeks. The control group except for the use of atorvastatin tablets outside the treatment group with the same observation. The changes of liver function indexes, serum hs-CRP, IL-6 and IL-10 levels in two groups before and after treatment were observed. [Results] The levels of ALT and GGT in two groups were significantly lower than those in the control group (P <0.05 or P <0.01) after 16 weeks treatment, and the decrease in the observation group was more obvious than that in the control group (P <0.05) hs-CRP and IL-6 levels were significantly lower than before, IL-10 levels were significantly increased (P <0.05 or P <0.01), and the changes in the observation group more obvious than the control group (P <0.05). [Conclusion] Atorvastatin adjuvant treatment of NASH is effective, can significantly improve liver function, and can reduce hs-CRP and IL-6 levels, increased anti-inflammatory factor IL-10 levels, thus correcting the proinflammatory cytokines and anti-inflammatory Factor imbalance, inhibition of intrahepatic immune damage to achieve the purpose of treatment.