【摘 要】
：
Hyocholic acid species (HCA,hyodeox-ycholic acid,and their glycine and tau-rine conjugated forms) comprise 80％ of the composition of pig bile (Haslewood,1956).An interesting fact about pigs is that they do not get diabetes even though they eat almost ever
【机 构】
：
Center for Translational Medicine,Shanghai Key Laboratory of Diabetes Mellitus,Department of Endocri
论文部分内容阅读
Hyocholic acid species (HCA,hyodeox-ycholic acid,and their glycine and tau-rine conjugated forms) comprise 80％ of the composition of pig bile (Haslewood,1956).An interesting fact about pigs is that they do not get diabetes even though they eat almost everything and in abundant amounts,a diabetes-promot-ing diet.The first use of pig bile for treat-ment of \'xiao-ke\',a condition known today as diabetes,was recorded ～400 years ago by the Chinese medical practi-tioners in the Compendium of Materia Medica (Li,1573-1593).Recently,we found HCA species as novel biomarkers for metabolic diseases (Zheng et al.,2021b) and also identified the role of HCA species in the prevention of diabe-tes as well as their mechanism of action(Zheng et al.,2021a).Although bile acids (BAs) are mostly associated with their aid in food digestion,they have also been shown to act as signaling mol-ecules by binding to two particular receptors,famesoid X receptor (FXR) and the G-protein-coupled receptor TGR5.Experiments were thus directed to the effect of HCA binding to these two BA receptors on glycemic regulation in both in vivo and in vitro models.
其他文献
Lipids exert many essential physiological functions,such as serving as a structural component of biological membranes,storing energy,and regulating cell signal transduction.Dysregulation of lipid metabolism can lead to dyslipidemia related to various hu-m
During embryonic heart development,the progenitor cells in the epicardium would migrate and differentiate into noncardiomyo-cytes in myocardium and affect the integrity of ventricular wall,but the underlying mechanism has not been well studied.We have fou
For a long period of time,intestinal mesenchymal stromal cells (IMSC) have been considered as a relatively simple and homogeneous group of cells.These cells could effectively regulate intestinal homeostasis and epithelium integrity via producing growth fa
Muscle regeneration after damage or during myopathies requires a fine cooperation between myoblast proliferation and myogenic differentiation.A growing body of evidence suggests that microRNAs play critical roles in myocyte proliferation and differentiati
Predicting potential lncRNA-disease as-sociation pairs is an important issue in the field of biomedicine.Traditional lncRNA-disease association prediction algorithms are mainly based on biologi-cal network models.
TDP43 pathology is seen in a large majority of amyotrophic lateral sclerosis (ALS) cases,suggesting a central pathogenic role of this regulatory protein.Clarifying the molecular mechanism controlling TDP43 stability and subcellular location might provide
构造Yang-Baxter方程的非退化对合集论解的问题可归结为构造所有右柱的问题.特别地,所有有限右柱的分类是描述Yang-Baxter方程所有这类解的基础.设H是pn阶右柱,(H,+)≌Zp×Zpn-1,其中n≥4,p是奇素数.本文证明了 |Soc(H)|≠1,并且给出了 |Soc(H)|＝pn-1的H的分类.
Accumulating evidence indicates that the alternative splicing program undergoes extensive changes during cancer develop-ment and progression.The RNA-binding protein QKI-5 is frequently downregulated and exhibits anti-tumor activity in lung cancer.Howeve-r
T cells have long been known as the core of adaptive immunity and play piv-otal roles in host defense (Zhu et al.,2010).There are two main types of T cells in our body,cytotoxic T cells(CD8+) and helper T (Th) cells (CD4+),the latter comprised of Th1,Th2,
Many cellular processes are orches-trated by dynamic changes in the plasma membrane to form membrane projec-tions and endocytic compartments in re-sponse to extracellular cue changes.Our previous studies show that post-transla-tional modifications of ACAP