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应用凝胶阻滞技术（gelretaldation），在甲基硝基亚硝胍（MNNG）诱发的遗传不稳定的Vero细胞（非洲绿猴肾细胞）抽提物中，发现存在特异性针对G·T的错配结合蛋白（mismatchbindingprotein），能选择性识别DNA中的G·T错配，并与之结合.经与正常Vero细胞相比较，证实其功能并无缺陷。从而排除了MNNG通过对错配结合蛋白功能的损伤而诱发细胞遗传不稳定的可能机制。
Gelretaldation was detected in extracts of genetically unstable Vero cells (African green monkey kidney cells) induced by methylnitrosoguanidine (MNNG) and found to be specific for G · T The mismatchbindingprotein, which selectively recognizes and binds G T mismatches in DNA, is flawless in comparison with normal Vero cells. Thus eliminating the possible mechanism by which MNNG induces cytogenetic instability by impairing the function of mismatch-binding proteins.