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多药抗药性产生机理张罩沐，许长江，张予（河南省医学科学研究所药理室，郑州４５００５２）肿瘤细胞的多药抗药性（Ｍｕｌｔｉｄｒｕｇｒｅｓｉｓｔａｎｃｅ，ＭＤＲ）是一种复杂的现象。早在１９７０年，Ｂｉｅｄｌｅｒ与Ｒｉｅｈｍ［１］就发现，Ｐ３８８白血病细胞及...
Mechanism of Multidrug Resistance Drug Resistance ZHANG Mu-Mu, XU Chang-Jiang, ZHANG Yu (Department of Pharmacology, Henan Institute of Medical Sciences, Zhengzhou 450052, China) Multidrug resistance (MDR) of tumor cells is a complex phenomenon. As early as 1970, Biedler and Riehm [1] discovered that P388 leukemia cells and...