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探讨了裂变产物~(147)Pm单次或连续多次摄入体内时的蓄积特性和诱发骨髓细胞突变效应 的相互关系。当~(147)Pm单次摄入机体后,早期呈选择性沉积于肝,5d后在骨髓中的沉积增升至首位,且呈表面型沉积。观察到可诱发骨髓细胞染色体畸变的发生,其畸变程度随体内摄入~(147)Pm的放射量的加大而相应增高。至于在~(147)Pm连续5d摄入机体后,从实验观察所得的滞留方程的慢相滞留半减期来见,要长达1155d之久,又从排除方程的慢组分半排期来看,也有121.58d。这些数据提示~(147)Pm摄入机体后,其自然排除极缓慢,有80％以上的~(147)Pm滞留在组织中,尤其在骨组织中呈选择性滞留,因而可引起骨髓细胞染色体畸变率的明显增升,值得指出的是,无论从~(147)Pm单次或连续多次摄入体内所诱发的畸变类型来看,大多是属于单体型的。
The relationship between the accumulation characteristics of the fission product ~(147)Pm after single or repeated ingestion in vivo and the mutagenic effects of bone marrow cells were investigated. When ~(147)Pm was ingested into the body for a single time, it was selectively deposited in the liver in the early stage. After 5 days, the deposition in the bone marrow increased to the top, and it was a surface deposition. The occurrence of chromosomal aberrations in bone marrow cells can be observed, and the degree of aberration increases with the increase in the amount of ~(147)Pm in the body. As for the ~(147)Pm ingestion of organisms for 5 days, the slow phase retention half-reduction period of the retention equation obtained from the experimental observation was observed to be as long as 1155 d, and it also came from the elimination of the slow component half-life of the equation. Look, there are also 121.58d. These data suggest that ~ (147) Pm intake after the body, the natural exclusion is very slow, there are more than 80% ~ (147) Pm retained in the organization, especially in the bone tissue was selective retention, which can cause bone marrow cell chromosome It is worth noting that the apparent increase in the distortion rate is due to the fact that the type of distortion induced by single or repeated ingestion of ~(147)Pm in vivo is mostly haplotype.