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目的分析特发性血小板减少性紫癜(ITP)患者的幽门螺杆菌(Hp)感染情况,探讨抗Hp治疗对Hp感染阳性ITP患者的疗效。方法 ITP组45例,正常对照组32例,利用双抗夹心ELISA法检测两组Hp感染情况,对Hp感染阳性的ITP患者在治疗ITP的同时加用抗Hp治疗,与ITP组中Hp阴性病例治疗后的血小板数进行比较。结果 ITP组及正常对照组的Hp检出阳性率分别为66.7%与43.8%,ITP组Hp阳性率明显较高(P<0.05);25例Hp阳性的ITP患者经抗Hp治疗后,转阴21例的血小板数明显高于ITP组中Hp阴性组(P<0.05);Hp根除后的21例中,有12例血小板计数明显上升或恢复正常。结论 ITP患者Hp感染阳性率高于正常人;抗Hp治疗可以提高Hp感染的部分ITP患者血小板数量;Hp感染可能与ITP发病有关。
Objective To analyze the infection of Helicobacter pylori (Hp) in patients with idiopathic thrombocytopenic purpura (ITP) and to evaluate the efficacy of anti-Hp therapy in patients with Hp-positive ITP. Methods 45 cases of ITP group and 32 cases of normal control group were used to detect the Hp infection status by double-antibody sandwich ELISA. The patients with positive Hp infection were treated with anti-Hp treatment while ITP treatment, and Hp-negative cases The number of platelets after treatment was compared. Results The positive rates of Hp in ITP group and normal control group were 66.7% and 43.8%, respectively, and the positive rate of Hp in ITP group was significantly higher (P <0.05). Twenty-five Hp-positive ITP patients after anti-Hp treatment were negative The number of platelets in 21 cases was significantly higher than that in ITP group (P <0.05). Of the 21 cases after Hp eradication, 12 cases had platelet counts significantly increased or returned to normal. Conclusion The positive rate of Hp infection in patients with ITP is higher than that in normal people. Anti-Hp treatment can increase the number of platelets in some ITP patients with Hp infection. Hp infection may be related to the pathogenesis of ITP.