本文首次用抗骨形成蛋白单克隆抗体(BMP-McAb)研究了骨形成蛋白(BMP)在伴有骨化的纤维性牙龈瘤中的分布情况。ABC 染色结果表明:BMP主要定位在骨基质中、骨母细胞内和部分胶原纤维组织内。骨内含钙的多少与染色的阳性程度成反比,光镜下不含骨的龈瘤中,部分纤维组织呈弱阳性反应,提示此部位可能发生骨化。 In this paper, the distribution of bone morphogenetic protein (BMP) in fibrous gingival tumors with ossification was studied for the first time with anti-bone morphogenetic protein monoclonal antibody (BMP-McAb). The results of ABC staining showed that BMP was mainly located in the bone matrix, in the osteoblasts and part of the collagen fibers. The amount of calcium in the bone was inversely proportional to the degree of positive staining. In the light microscope without bone, some fibrous tissues showed a weak positive reaction, suggesting that ossification may occur at this site.