The design of full-order robust H-infinity estimators is investigated for continuous-time polytopic uncertain systems. The main purpose is to obtain a stable and proper linear estimator such that the estimation error system remains robustly stable with a prescribed H-infinity attenuation level. Based on a recently proposed H-infinity performance criterion which exhibits a kind of decoupling between the Lyapunov matrix and the system dynamic matrices, a sufficient condition for the existence of the robust estimator is provided in terms of linear matrix inequalities. It is shown that the proposed design strategy allows the use of parameter-dependent Lyapunov functions and hence it is less conservative than earlier results. A numerical example is employed to illustrate the feasibility and advantage of the proposed design.