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目的探讨西比灵添加治疗难治性癫痫的临床研究。方法对101例难治性癫痫患者(成人59例,小儿42例)采用开放性试验的方法进行添加治疗。结果作为添加剂的西比灵治疗难治性的癫痫,总有效率达50.1%,发作停止22.1%的患者。对复杂的部分性发作有效率达69%,对其他类型治疗前后的心电图及血、肾、尿、肝等化验无明显的变化有一定的效果,偶有出现轻度的副作用但不影响患者的结果。结论西比灵是对癫痫发作造成的神经元损伤有保护作用,且是一种安全有效的辅助抗癫痫药。
Objective To investigate the clinical study of xibiben adding refractory epilepsy. Methods A total of 101 patients with refractory epilepsy (59 adults and 42 children) were treated with an open test. Results Sibelium as an additive in the treatment of refractory epilepsy, with a total effective rate of 50.1%, 22.1% of patients with seizures stopped. The efficiency of complex partial seizures up to 69%, before and after treatment of other types of ECG and blood, kidney, urine, liver and other tests had no effect on the change, occasionally mild side effects but does not affect the patient’s result. Conclusion Sibelium is protective against neuronal damage caused by epileptic seizures and is a safe and effective auxiliary antiepileptic drug.