骨骼肌细胞内蛋白降解有多种途径 ,其中泛在素 蛋白酶体 (Ｕｂｉｑｕｉｔｉｎ ｐｒｏｔｅａｓｏｍｅ)途径是近 2 0年来发现的高效细胞内蛋白降解机制。本文就泛在素 蛋白酶体途径的组成及作用机制、分解代谢状态下的泛在素 蛋白酶体途径、骨骼肌蛋白降解的调节机制和治疗展望 There are many ways of protein degradation in skeletal muscle cells, among which the Ubiquitin proteasome pathway is a highly efficient mechanism of intracellular protein degradation found in the past 20 years. In this paper, the composition and mechanism of the ubiquitin proteasome pathway, the ubiquitin proteasome pathway in catabolic state, the regulation mechanism of skeletal muscle protein degradation and its therapeutic prospect